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Polyfunctional Gag-specific CD8 T cells. (A) Elite controllers have increased percentages of Gag-specific IFN-γ+ TNF-α+ CD107a+ T cells, while levels of pp65-specific IFN-γ+ TNF-α+ CD107a+ T cells are similar in every group. (B) The TEM/Mem ratio for Gag-specific IFN-γ+ TNF-α+ CD107a+ T cells is increased in elite controllers. TEM cells, CD45RO+ CD27− cells; Mem cells, CD45RO+ CD27+ cells; EC, elite controllers; RC, relative controllers; NC, noncontrollers.
