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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Thorax. 2011 Jun 16;66(10):894–902. doi: 10.1136/thoraxjnl-2011-200154

Table 4.

SNPs associated with the current CPD (square-root transformed) with meta-analytic p<10-5, and candidate SNPs from CHRNA3/CHRNA5 and CYP2A6 loci identified by previous studies

Chr. Top SNP Nearest gene within 50kb Effect/Non- Effect allele B p I2 Q stat. N/Nimp Freq. Effect direction consistent with previous studies
Top SNPs 3 rs1881681 - C/A 0.363 1.22×10−6 33 0.22 3/0 0.88 -
8 rs11984631 - T/G 1.351 1.56×10−6 37 0.21 2/0 0.99 -
2 rs12615264 SOCS5 (3’ region) T/G 0.644 3.46×10−6 0 0.38 3/3 0.03 -
2 rs11682595 SOCS5 (3’ region) T/G 0.642 3.49×10−6 0 0.41 3/3 0.03 -
2 rs11125090 SOCS5 (3’ region) A/G 0.641 3.58×10−6 0 0.42 3/2 0.03 -
20 rs297755 - G/A 0.291 4.86×10−6 49 0.14 3/3 0.17 -
4 rs3893377 BST1 (3’ region) C/T 0.289 4.90×10−6 51 0.13 3/3 0.80 -
4 rs10019008 BST1 (3’ region) C/T 0.288 4.99×10−6 53 0.12 3/0 0.80 -
4 rs11947310 BST1 (3’ region) A/C 0.289 5.21×10−6 53 0.12 3/3 0.80 -
4 rs10018756 BST1 (3’ region) A/T 0.275 7.71×10−6 48 0.15 3/3 0.77 -
Candidate SNPs 15 rs1051730 CHRNA3 (exon, Tyr215Tyr) G/A 0.010 0.851 32 0.23 3/0 0.59 No
15 rs16969968 CHRNA5 (exon, Asp398Asn) G/A 0.009 0.863 30 0.24 3/2 0.59 No
15 rs8034191 AGPHD1 (intron) T/C 0.006 0.914 5 0.35 3/0 0.59 No
15 rs684513 CHRNA5 (intron) C/G 0.100 0.153 0 0.78 3/3 0.80 Yes
15 rs578776 CHRNA3 (3’ UTR) G/A 0.052 0.388 0 0.98 3/0 0.76 Yes
15 rs588765 CHRNA5 (intron) T/C 0.048 0.352 23 0.27 3/3 0.40 No
19 rs3733829 EGLN2 (intron) G/A 0.005 0.930 40 0.19 3/2 0.39 Yes
19 rs7937 RAB4B (3’ UTR) T/C 0.027 0.590 0 0.37 3/0 0.60 Yes
19 rs1801272 CYP2A6 (exon, Leu160His) A/T 0.362 0.063 0 1.00 3/3 0.96 Yes
19 rs4105144 CYP2A6 (5’ region) C/T 0.069 0.217 0 0.55 3/3 0.73 Yes
19 rs7260329 CYP2B6 (intron) G/A 0.005 0.922 0 0.76 3/0 0.68 Yes
19 rs7251570 CYP2A6 (3’ region) G/A 0.105 0.052 0 0.87 3/3 0.71 Yes
19 rs12461383 CYP2A7 (3’ region) G/C 0.143 0.008 0 0.62 3/3 0.60 Yes

Analyses were adjusted for sex, age, % of predicted FEV1 and principal components for genetic ancestry. N/Nimp =Number of studies contributing to meta-analysis / number of studies where SNP was imputed; I2=heterogeneity index; Q stat.=p value for Q statistic; p=p value from the fixed effect meta-analysis; SNP=Single Nucleotide Polymorphism; CPD=number of cigarettes smoked per day; Freq. = Effect allele frequency in 3,441 subjects with at least 1 non-missing phenotype from 4 cohorts studied; Chr.=Chromosome; B=regression coefficient; UTR=Untranslated Region;CHRNA3/CHRNA5=alpha-nicotinic acetylcholine receptor 3/5;CYP2A6=Cytochrome P450 2A6