. Author manuscript; available in PMC: 2012 Dec 8.

Published in final edited form as: J Med Chem. 2011 Nov 10;54(23):8078–8084. doi: 10.1021/jm201226w

Table 1.

Structures of ligands screened for MC1R selectivity.

Compound	Structure
1	4-phenylbutyryl-His-DPhe-Arg-Trp-NH₂
2	Ac-Homophenylalanine-His-DPhe-Arg-Trp-NH₂
3	4-hydroxycinnamoyl-His-DPhe-Arg-Trp-NH₂
4	4-phenylbutyryl-His-DPhe-Arg-Trp-Gly-Lys(hex-5-ynoyl)-NH₂
5	H-Tyr-Val-Nle-Gly-His-DNal(2′)-Arg-DTrp-Asp-Arg-Phe-Gly-NH₂
6	H-Lys(hex-5-ynoyl)-Tyr-Val-Nle-Gly-His-DNal(2′)-Arg-DTrp-Asp-Arg-Phe-Gly-NH₂
7	H-Tyr-Val-Nle-Gly-His-DNal(2′)-Arg-DPhe-Asp-Arg-Phe-Gly-NH₂
8	H- Lys(hex-5-ynoyl)Tyr-Val-Nle-Gly-His-DNal(2′)-Arg-DPhe-Asp-Arg-Phe-Gly-NH₂