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. Author manuscript; available in PMC: 2012 Dec 8.
Published in final edited form as: J Med Chem. 2011 Nov 10;54(23):8078–8084. doi: 10.1021/jm201226w

Table 2.

Affinity and selectivity of ligands assayed in this publication.

Ki (nM)
Ligand MC1R MC4R MC5R 1R/4R 1R/5R
1 0.17 160 27 950 160
2 1.8 988 58 560 33
3 NB⫞ NB NB - -
4 0.24 254 46 1058 192
5 2.0 0.75 0.76 0.38 0.38
6 2.6 1.7 1.4 0.67 0.57
7 5.6 0.77 0.71 0.13 0.13
8 4.2 4.4 3.9 1.0 0.93
4-targeted polymer 26 NB NB - -
4-targeted micelles 2.9 NB NB - -
NDP-a-MSH 1.8 19 9.9 10 5.5
⫞

NB = Non-binding.