Table 5.
Conformational flexibility of the OTEMO-FAD-NADP structures observed in different OTEMO subunitsa
| Subunit (PDB accession no.) | Conformation at residues: |
Type | |||
|---|---|---|---|---|---|
| 145–152 | 390–394 | 435–444 | 497–518 | ||
| NADP form 1-A (3UOY) | Open | Disordered | Conformer 1 | Open (β-hairpin) | 1 |
| NADP form 1-B (3UOY) | Closed | Disordered | Conformer 1 | Open (β-hairpin) | 2 |
| NADP form 2-A (3UOZ) | Closed | Ordered | Conformer 2 | Open (β-hairpin) | 3 |
| NADP form 2-B (3UOZ) | Closed | Ordered | Conformer 2 | Open (β-hairpin) | 3 |
| NADP form 3-A (3UP4) | Closed | Ordered | Conformer 3 | Closed | 4 |
| NADP form 3-B (3UP4) | Closed | Ordered | Conformer 3 | Closed | 4 |
| NADP form 4-A (3UP5) | Open | Disordered | Conformer 1 | Open (β-hairpin) | 1 |
| NADP form 4-B (3UP5) | Closed | Ordered | Conformer 3 | Closed | 4 |
a
The four segments listed here are indicated by the letters A, B, C, and D in Fig. 4D.