Table 2.
Piperacillin-tazobactam pharmacokinetics in 42 intensive care unit patients receiving continuous renal replacement therapy
| Total Drug | Free Drug | |
|---|---|---|
| Piperacillin PK parameters | ||
| protein binding (%) | 19.0±9.7 | |
| Vd (L) | 34.5 (30.5) | 38.2 (26.5) |
| Vd (L/kg) | 0.38 (0.20) | 0.43 (0.26) |
| ke (h−1) | 0.104 (0.052) | 0.120 (0.073) |
| t1/2 (hours) | 9.6 (4.2) | 5.8 (3.6) |
| clearance (ml/min) | 64.5 (59.7) | 78.6 (62.2) |
| CRRT clearance (ml/min) | 27.6 (15.2) | 33.2 (14.9) |
| Tazobactam PK parameters | ||
| protein binding (%) | 14.6 (36.5) | |
| Vd (L) | 38.1 (27.6) | 50.6 (54.1) |
| Vd (L/kg) | 0.38 (0.33) | 0.50 (0.56) |
| ke (h−1) | 0.086 (0.058) | 0.089 (0.063) |
| t1/2 (hours) | 11.5 (9.4) | 7.8 (6.3) |
| clearance (ml/min) | 48.3 (46.5) | 83.6 (86.5) |
| CRRT clearance (ml/min) | 25.7 (15.3) | 35.7 (17.8) |
Data are presented as mean ± SD or median (intraquartile range). PK, pharmacokinetic; CRRT, continuous renal replacement therapy.