Table 2.
Mean differences in annual rate of cognitive decline for an eGFR <60 ml/min per 1.73 m2 compared with an eGFR ≥60 ml/min per 1.73 m2
| Age-Adjusted Only (95% CI) | Multivariable Adjusteda (95% CI) | |
|---|---|---|
| eGFR <60 ml/min per 1.73 m2 (CKD-EPI) (n=408) | ||
| global cognitive score | −0.003 (−0.02, 0.02) | −0.002 (−0.02, 0.02) |
| verbal memory composite score | −0.003 (−0.03, 0.02) | −0.002 (−0.02, 0.02) |
| verbal fluency score | −0.006 (−0.14, 0.13) | 0.002 (−0.14, 0.15) |
| TICS score | −0.06 (−0.14, 0.02) | −0.05 (−0.14, 0.03) |
| eGFR < 60 ml/min per 1.73 m2 (cystatin C)b (n=665) | ||
| global cognitive score | 0.004 (−0.02, 0.02) | 0.0005 (−0.02, 0.02) |
| verbal memory composite score | 0.004 (−0.02, 0.03) | −0.001 (−0.03, 0.02) |
| verbal fluency score | 0.03 (−0.12, 0.17) | 0.01 (−0.004, 0.004) |
| TICS score | −0.03 (−0.12, 0.06) | −0.02 (−0.11, 0.07) |
| eGFR < 60 ml/min per 1.73 m2 (PCr + cystatin C)b (n=329) | ||
| global cognitive score | −0.01 (−0.03, 0.008) | −0.02 (−0.04, 0.01) |
| verbal memory composite score | −0.02 (−0.04, 0.01) | −0.02 (−0.05, 0.01) |
| verbal fluency score | 0.02 (−0.14, 0.18) | −0.01 (−0.18, 0.16) |
| TICS score | −0.03 (−0.10, 0.04) | −0.04 (−0.14, 0.05) |
95% CI, 95% confidence interval; eGFR, estimated GFR; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration equation; TICS, telephone interview for cognitive status; PCr, plasma creatinine.
a
Adjusted for age, hypertension, body mass index, diabetes, cigarette smoking, cardiovascular disease, alcohol intake, physical activity (METs/wk), high cholesterol, participant education level, spouse’s education level, and postmenopausal hormone use.
b
Cystatin C was measured in 1110 participants.