Table 3.
Mean differences in annual rate of cognitive decline for an ACR ≥5 mg/g and ≥10 mg/g compared with lower levels
| Age-Adjusted Only (95% CI) | Multivariable Adjusteda (95% CI) | |
|---|---|---|
| ACR ≥5 mg/g (n=440) | ||
| global cognitive score | −0.03 (−0.05, −0.01) | −0.03 (−0.05, −0.01) |
| verbal memory composite score | −0.03 (−0.05, −0.004) | −0.02 (−0.05, −0.001) |
| verbal fluency score | −0.18 (−0.31, −0.04) | −0.19 (−0.34, −0.05) |
| TICS score | −0.09 (−0.16, −0.009) | −0.09 (−0.17, −0.004) |
| ACR ≥10 mg/g (n=228) | ||
| global cognitive score | −0.03 (−0.05, −0.009) | −0.04 (−0.06, −0.01) |
| verbal memory composite score | −0.02 (−0.05, 0.005) | −0.02 (−0.05, 0.01) |
| verbal fluency score | −0.16 (−0.33, 0.02) | −0.19 (−0.38, −0.01) |
| TICS score | −0.13 (−0.23, −0.03) | −0.13 (−0.24, −0.02) |
95% CI, 95% confidence interval; ACR, urinary albumin/creatinine ratio; TICS, telephone interview for cognitive status.
a
Adjusted for age, hypertension, body mass index, diabetes, cigarette smoking, cardiovascular disease, alcohol intake, physical activity (METS/wk), high cholesterol, participant education level, spouse’s education level, and postmenopausal hormone use.