Table I.
Group 1 (n = 11) (Montelukast) | Group 2 (n = 11) Fluticasone) | Group 3 (n = 10) (SR-Theophylline) | Group 4 (n = 7) (No medication) | |||||
---|---|---|---|---|---|---|---|---|
Baseline | Day 56 | Baseline | Day 56 | Baseline | Day 56 | Baseline | Day 56 | |
± SD | ± SD | ± SD | ± SD | ± SD | ± SD | ± SD | ± SD | |
Age | 10.0 ±1.95 | 9.7 ±2.01 | 9.6 ±0.97 | 9.9 ±2.91 | ||||
FEV1% | 68 ±10* | 78 ±13* | 72 ±15 | 81 ±11 | 76 ±9* | 86 ±11* | 75 ±14 | 73 ±21 |
PEFR% | 63 ±17* | 76 ±11* | 59 ±15* | 75 ±15* | 65 ±18 | 73 ±11 | 67 ±19 | 62 ±17 |
NO [μmol/l] | 4.9 ±3.9* | 2.2 ±2.1* | 3.2 ±2.5* | 1.4 ±1.7* | 3.7 ±2.4 | 2.3 ±2.7 | 2.4 ±3.6 | 4.5 ±5.2 |
Eosin% | 6.0 ±2.0* | 3.0 ±1.0* | 9.0 ±4.0* | 4.0 ±3.0* | 5.0 ±3.0* | 2.0 ±2.0* | 3.0 ±2.0 | 2.0 ±1.0 |
* p = significant (p < 0.05) improvement in parameter after 8 weeks of treatment; for FEV % p = 0.007 and 0.012 (in groups 1 and 3 respectively for PEFR% p = 0.028 and 0.003 (in groups 1 and 2 respectively); for NO p = 0.041 and 0.026 (in groups 1 and 2 respectively); and for Eosin% p = 0.001, 0.000 and 0.002 (in groups 1, 2 and 3 respectively)
FEV1%–forced expiratory flow rate at first second as percentage of that predicted, PEFR%–peak expiratory flow rate as percentage of tha predicted, Eosin%–eosinophil count as percentage of eosinophils