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. 2011 Apr 13;31(15):5744–5754. doi: 10.1523/JNEUROSCI.6810-10.2011

Figure 5.

Figure 5.

Extensive axonal regeneration and large polyaxonal pockets in the distal segment of crushed BACE1 KO sciatic nerve at 5 d after crush. A–F are electron micrographs. A, WT nerve. Abundant myelin debris and ovoids and few regenerating sprouts are present (arrow). B, BACE1 KO nerve. Myelin debris is cleared and numerous regenerating sprouts (arrows) are present. C, WT nerve. Few polyaxonal pockets are present. D, BACE1 KO nerve. Numerous polyaxonal pockets (arrows) are present. E, WT nerve. A degenerating myelinated fiber has one (arrow) sprout growing beneath the basal lamina membrane. F, BACE1 KO nerve. Multiple sprouts (arrows) are growing within individual degenerating fibers. G, The BACE1 KO fibers exhibit enhanced number of regenerating sprouts within a single basal lamina membrane compared with WT fibers. For example, 66% of the BACE1 KO fibers have two or more regenerating sprouts compared with 31% of the WT fibers, which have two or more sprouts. Scale bars: A–D, 2 μm.