Figure 8.

Robust reinnervation of neuromuscular junctions in BACE1 KO versus WT at 10 d after crush. Ten days after nerve crush, the gastrocnemius muscle was harvested from BACE1 KO and WT mice. A and B are stained for synaptophysin; C and D are stained for α-bungarotoxin. E and F are merged images of A and C, and B and D, respectively. Reinnervating presynaptic endings at neuromuscular junctions in BACE1 KO appeared more mature than those in WT. G, Counts of neuromuscular junctions in WT and BACE1 KO mice. BACE1 KO muscles have significantly more reinnervated junctions. N = 3 per genotype. Values are mean ± SEM. *p < 0.05.