Table 5. The MIC range, MIC₅₀, MIC₉₀, and geometric mean for all 493 C. neoformans isolates for seven antifungals according to clinical and environmental origin of isolates.

Isolates	Antifungal agent	MIC
		Range	MIC50	Geometric Mean	MIC90
All C. neoformans isolates (n = 493)	Amphotericine B	0.063–1	0.25	0.251	0.5
	5-Flucytosine	<0.063–>64	4	3.483	8
	Fluconazole	0.125–32	2	2.294	4
	Itraconazole	<0.016–0.5	0.063	0.063	0.25
	Voriconazole	<0.016–0.5	0.063	0.049	0.125
	Posaconazole	<0.016–0.5	0.063	0.061	0.125
	Isavuconazole	<0.016–0.125	0.031	0.027	0.063
Isolates from HIV-positive patients (n = 236)	Amphotericine B	0.063–1	0.25	0.236	0.5
	5-Flucytosine	<0.063–>64	4	3.816	8
	Fluconazole	0.125–32	2	2.532	4
	Itraconazole	<0.016–0.5	0.063	0.062	0.25
	Voriconazole	<0.016–0.5	0.063	0.055	0.125
	Posaconazole	<0.016–0.5	0.063	0.062	0.125
	Isavuconazole	<0.016–0.125	0.031	0.025	0.063
Isolates from HIV-negative patients (n = 156)	Amphotericine B	0.063–1	0.25	0.253	0.5
	5-Flucytosine	0.25–32	4	3.091	8
	Fluconazole	0.125–16	2	2.072	4
	Itraconazole	<0.016–0.25	0.063	0.057	0.125
	Voriconazole	<0.016–0.25	0.063	0.036	0.125
	Posaconazole	<0.016–0.25	0.063	0.054	0.125
	Isavuconazole	<0.016–0.125	0.031	0.024	0.063
Clinical isolates from Thailand and Japan (n = 68)	Amphotericine B	0.063–0.5	0.25	0.291	0.5
	5-Flucytosine	0.5–8	4	3.433	8
	Fluconazole	0.25–32	2	2.452	4
	Itraconazole	<0.016–0.25	0.063	0.058	0.125
	Voriconazole	<0.016–0.5	0.063	0.070	0.125
	Posaconazole	<0.016–0.125	0.063	0.057	0.125
	Isavuconazole	<0.016–0.125	0.031	0.026	0.063
Environmental isolates from Thailand and Japan	Amphotericine B	0.125–0.5	0.25	0.286	0.5
(n = 67)	5-Flucytosine	0.063–8	4	2.933	4
	Fluconazole	0.125–8	2	2.106	4
	Itraconazole	<0.016–0.5	0.125	0.095	0.25
	Voriconazole	<0.016–0.125	0.063	0.055	0.125
	Posaconazole	<0.016–0.25	0.125	0.090	0.125
	Isavuconazole	<0.016–0.063	0.063	0.039	0.063