Skip to main content
. 2012 Mar 13;7(3):e33418. doi: 10.1371/journal.pone.0033418

Figure 3. Lactate induces an increase in HIF-1α protein expression in normoxic endothelial cells.

Figure 3

HIF-1α protein expression was detected by western blot in normoxic ECs. (A) HUVECs were incubated during 24-h with 10 mM lactate or not. **p = 0.0014; n = 8. (B) as in (A) but with BAECs. ***p<0.0001; n = 16–17. (C) BAECs were incubated during 24-h with the indicated concentrations of lactate. **p<0.01; n = 4. (D) BAECs were incubated during the indicated times with 10 mM of lactate. *p<0.05; n = 5–12. (A–D) Error bars reflect mean ± SEM.