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. 2012 Mar 13;7(3):e33250. doi: 10.1371/journal.pone.0033250

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A. Protein expression of the sulfatase modifying factor (SUMF)-1 was not reduced by hypoxia (10% O₂×4 h) in the BEC or the NCM460 cells. B. Knockdown by siRNA for SUMF-1 effectively reduced the protein expression measured by ELISA in the NCM460 cells. C. ARSB activity was significantly reduced by siRNA for SUMF-1 (p<0.001), and additional reduction occurred in association with hypoxia (10% O₂×4 h) (p<0.001) in the NCM460 cells, consistent with a requirement for both SUMF-1 and molecular oxygen for maximum ARSB activity. [ARSB = arylsulfatase B; BEC = bronchial epithelial cell].