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. 2012 Mar 13;7(3):e33250. doi: 10.1371/journal.pone.0033250

Figure 5. ARSB silencing and hypoxia reduce the GSH/GSSG ratio.

Figure 5

A. In the BEC, the ratio of reduced glutathione (GSH) to glutathione disulfide declined significantly following hypoxia (10% O2×4 h) and following ARSB silencing by siRNA (p<0.001). These effects are consistent with decline in the overall reduced status of the cells. B. Similarly, in the NCM460 cells, the reduced glutathione to glutathione disulfide was markedly reduced, attributable to decline in the reduced glutathione (p<0.001) following 10% O2×4 h. [BEC = bronchial epithelial cell; ARSB = arylsulfatase B].