Table 4. Multi-modal combined experiment with [3H]PiB/[11C]PiB cocktail.
| modality | AD1* | AD2 | CTL1* | CTL2 | ||
| PET [BPND neocortex] | 0.06 | 0.06 | −0.06 | −0.07 | ||
| Biodistribution [11C]PiB [region-to-cerebellum ratio] | olfactory system | 1.00 | 1.07 | 1.05 | 0.98 | |
| telencephalon | 1.24 | 1.24 | 0.92 | 0.92 | ||
| diencephalon and midbrain | 1.26 | 1.47 | 1.22 | 1.10 | ||
| Autoradiography [neocortex-to-cerebellum ratio] | [11C]PiB | 1.88 | 2.1 | 0.72 | 0.95 | |
| [3H]PiB | 1.26 | 1.24 | 0.90 | 0.97 | ||
| Histology [% plaque area neocortex] | Thioflavin S | 4.00 | 4.10 | 0.54 | 0.41 | |
| Aβx–40 | 3.63 | 3.57 | ||||
| Aβx–42 | 5.88 | 6.14 | 0.02 | 0.01 | ||
| Aβ protein levels (forebrain) [pg protein/mg tissue wet weight] | soluble | Aβx–40 | 272.0 | 212.1 | ||
| Aβx–42 | 267.3 | 191.3 | ||||
| insoluble | Aβx–40 | 91522.8 | 117849.6 | |||
| Aβx–42 | 134335.4 | 164156.0 | ||||
An all-in-one experiment was performed for four animals of the young study groups (2 tgtg-young (AD1 and AD2) and 2 ctl-young (CTL1 and CTL2)) to retrieve a large spectrum of multi-modal information from a single animal. Asterisk (*) marks animals that are shown in Figure 6.