Table 5.
Effects of sActRIIB treatment on muscle force in mice bearing the Lewis lung carcinoma
C | T | T + A | |
---|---|---|---|
Grip force (day 0) | 5.1 ± 0.21a,c | 4.7 ± 0.20a,c | 5.2 ± 0.24a,c |
Grip force (day 14) | 5.0 ± 0.23a,c | 2.8 ± 0.16b,d | 4.4 ± 0.3a,c |
Grip force is expressed as grams per gram IBW. Results are mean ± S.E.M. Statistical significance of the results by one-way analysis of variance (ANOVA). Statistically significant difference by post hoc Duncan test. Different letters in superscript indicate significant differences between groups (a and b: differences between C, T, and T + A groups the same day of measurement; and c and d: differences between days 0 and 14 in the same group)
C control mice (n = 4), T tumor-bearing mice (n = 8), T + A tumor-bearing mice treated with sActRIIB (n = 8)