Table 5.

Summary of CYP activity in the HH (3 donors), HepaRG, and HepG2 cells after exposure to vehicule, BNF, PB, and RIF

CYP1A2, 2B6, and 3A4 activities were measured using ethoxyresorufin O-deethylase, bupropion hydroxylation (BPH), and midazolam as respective catalytic probes. Values in (a) represent the basal and induced activities; values in (b) represent the average fold change (technical triplicates) compared to vehicle treated cells. Standard deviation is indicated between brackets. Fold changes >2 and <5 are colored in yellow, >5 and <10 in orange, and >10 in red

ND no data reported for BPH activity due to technical problem, BLQ below detection limit