Fig 5.

Filamin-A expression sensitizes C8161 melanoma cells to etoposide treatment in xenograft mouse model. Human melanoma tumor xenografts were generated as described previously. Shown is the tumor growth in response to control (saline) and etoposide treatment. Treatment group was administrated with etoposide at the dosage of 5 mg/Kg, with 3 days interval and 7 administrations total. Control group was injected with same volume of saline. Error bars represent the standard errors from 5 mice. Red arrow shown in figure indicates the significant growth delay was observed in filamin-A proficient tumors compared with filamin-A deficient tumors (p < 0.05) at 24 days and thereafter with etoposide treatments.