Table 2.
Allele and genotype frequencies as well as Hardy-Weinberg Equilibrium according to the investigated polymorphisms
| TNF-alpha -308G>A (rs1800629) polymorphism | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Allele frequencies, n (%) | Genotype frequencies, n (%) | |||||||||
| Author | Participants | Disease status | Study size | HWE | G | A | GG | GA | AA | |
| Trabace 2002 (20) | all | controls | 101 | 0.052 | 189 (93.6) | 13 (6.4) | 90 (89.1) | 9 (8.9) | 2 (2.0) | |
| migraine | 79 | 1.000 | 146 (92.4) | 12 (7.6) | 67 (84.8) | 12 (15.2) | 0 (0.0) | |||
| MA | 32 | 1.000 | 57 (89.1) | 7 (10.9) | 25 (78.1) | 7 (21.9) | 0 (0.0) | |||
| MO | 47 | 1.000 | 89 (94.7) | 5 (5.3) | 42 (89.4) | 5 (10.6) | 0 (0.0) | |||
| females | controls | 45 | 0.116 | 85 (94.4) | 5 (5.6) | 41 (91.1) | 3 (6.7) | 1 (2.2) | ||
| migraine | 62 | 1.000 | 114 (91.9) | 10 (8.1) | 52 (83.9) | 10 (16.1) | 0 (0.0) | |||
| MA | 27 | 1.000 | 48 (88.9) | 6 (11.1) | 21 (77.8) | 6 (22.2) | 0 (0.0) | |||
| MO | 35 | 1.000 | 66 (94.3) | 4 (5.7) | 31 (88.6) | 4 (11.4) | 0 (0.0) | |||
| males | controls | 56 | 0.234 | 104 (92.9) | 8 (7.1) | 49 (87.5) | 6 (10.7) | 1 (1.8) | ||
| migraine | 17 | 1.000 | 32 (94.1) | 2 (5.9) | 15 (88.2) | 2 (11.8) | 0 (0.0) | |||
| MA | 5 | 1.000 | 9 (90.0) | 1 (10.0) | 4 (80.0) | 1 (20.0) | 0 (0.0) | |||
| MO | 12 | 1.000 | 23 (95.8) | 1 (4.2) | 11 (91.7) | 1 (8.3) | 0 (0.0) | |||
| Rainero 2004 (16) | all | controls | 306 | 0.693 | 502 (82.0) | 110 (18.0) | 207 (67.6) | 88 (28.8) | 11 (3.6) | |
| migraine | 299 | 1.000 | 554 (92.6) | 44 (7.4) | 256 (85.6) | 42 (14.0) | 1 (0.3) | |||
| MA | 38 | 1.000 | 66 (86.8) | 10 (13.2) | 28 (73.7) | 10 (26.3) | 0 (0.0) | |||
| MO | 261 | 1.000 | 488 (93.5) | 34 (6.5) | 228 (87.4) | 32 (12.3) | 1 (0.4) | |||
| females | controls | 231 | 1.000 | 382 (82.7) | 80 (17.3) | 158 (68.4) | 66 (28.6) | 7 (3.0) | ||
| migraine | 215 | 0.611 | 401 (93.3) | 29 (6.7) | 186 (86.5) | 29 (13.5) | 0 (0.0) | |||
| males | controls | 75 | 0.475 | 120 (80.0) | 30 (20.0) | 49 (65.3) | 22 (29.3) | 4 (5.3) | ||
| migraine | 84 | 0.504 | 153 (91.1) | 15 (8.9) | 70 (83.3) | 13 (15.5) | 1 (1.2) | |||
| Herken 2005 (23) | all | controls | 62 | 1.000 | 115 (92.7) | 9 (7.3) | 53 (85.5) | 9 (14.5) | 0 (0.0) | |
| migraine | 60 | 0.170 | 113 (94.2) | 7 (5.8) | 54 (90.0) | 5 (8.3) | 1 (1.7) | |||
| MA | 40 | 1.000 | 76 (95.0) | 4 (5.0) | 36 (90.0) | 4 (10.0) | 0 (0.0) | |||
| MO | 20 | 0.079 | 37 (92.5) | 3 (7.5) | 18 (90.0) | 1 (5.0) | 1 (5.0) | |||
| Mazaheri 2006 (15) | all | controls | 183 | 0.0004 | 274 (74.9) | 92 (25.1) | 94 (51.4) | 86 (47) | 3 (1.6) | |
| MO | 221 | <0.0001 | 265 (60) | 177 (40) | 51 (23.1) | 163 (73.8) | 7 (3.2) | |||
| females | controls | 123 | 0.001 | 191 (77.6) | 55 (22.4) | 68 (55.3) | 55 (44.7) | 0 (0.0) | ||
| MO | 196 | <0.0001 | 233 (59.4) | 159 (40.6) | 44 (22.4) | 145 (74) | 7 (3.6) | |||
| males | controls | 60 | 0.141 | 83 (69.2) | 37 (30.8) | 26 (43.3) | 31 (51.7) | 3 (5.0) | ||
| MO | 25 | 0.007 | 32 (64.0) | 18 (36.0) | 7 (28.0) | 18 (72.0) | 0 (0.0) | |||
| Lee 2007 (21) | all/females | controls | 382 | 0.158 | 717 (93.8) | 47 (6.2) | 338 (88.5) | 41 (10.7) | 3 (0.8) | |
| migraine | 439 | 0.716 | 815 (92.8) | 63 (7.2) | 377 (85.9) | 61 (13.9) | 1 (0.2) | |||
| MA | 65 | 1.000 | 119 (91.5) | 11 (8.5) | 54 (83.1) | 11 (16.9) | 0 (0.0) | |||
| MO | 327 | 1.000 | 608 (93.0) | 46 (7.0) | 282 (86.2) | 44 (13.5) | 1 (0.3) | |||
| Asuni 2009 (19) | all | controls | 278 | 0.560 | 526 (94.6) | 30 (5.4) | 249 (89.6) | 28 (10.1) | 1 (0.4) | |
| MO | 299 | 0.476 | 570 (95.3) | 28 (4.7) | 272 (91.0) | 26 (8.7) | 1 (0.3) | |||
| females | controls | 144 | 1.000 | 273 (94.8) | 15 (5.2) | 129 (89.6) | 15 (10.4) | 0 (0.0) | ||
| MO | 261 | 0.452 | 497 (95.2) | 25 (4.8) | 237 (90.8) | 23 (8.8) | 1 (0.4) | |||
| males | controls | 134 | 0.333 | 253 (94.4) | 15 (5.6) | 120 (89.6) | 13 (9.7) | 1 (0.7) | ||
| MO | 38 | 1.000 | 73 (96.1) | 3 (3.9) | 35 (92.1) | 3 (7.9) | 0 (0.0) | |||
| Schürks 2009 (17) | all/females | controls | 20,425 | 0.559 | 33,771 (82.7) | 7079 (17.3) | 13947 (68.3) | 5877 (28.8) | 601 (2.9) | |
| migraine | 4577 | 0.094 | 7531 (82.3) | 1623 (17.7) | 3081 (67.3) | 1369 (29.9) | 127 (2.8) | |||
| MA | 1275 | 0.420 | 2060 (80.8) | 490 (19.2) | 827 (64.9) | 406 (31.8) | 42 (3.3) | |||
| MO | 1951 | 0.868 | 3240 (83.0) | 662 (17.0) | 1346 (69.0) | 548 (28.1) | 57 (2.9) | |||
| Ghosh 2010 (14) | all | controls | 216 | 0.557 | 406 (94.0) | 26 (6.0) | 191 (88.4) | 24 (11.1) | 1 (0.5) | |
| migraine | 216 | 0.235 | 391 (90.5) | 41 (9.5) | 175 (81.0) | 41 (19.0) | 0 (0.0) | |||
| MA | 84 | 0.595 | 149 (88.7) | 19 (11.3) | 65 (77.4) | 19 (22.6) | 0 (0.0) | |||
| MO | 132 | 0.604 | 242 (91.7) | 22 (8.3) | 110 (83.3) | 22 (16.7) | 0 (0.0) | |||
| females | controls | 152 | 0.446 | 285 (93.8) | 19 (6.3) | 134 (88.2) | 17 (11.2) | 1 (0.7) | ||
| migraine | 152 | 0.363 | 273 (89.8) | 31 (10.2) | 121 (79.6) | 31 (20.4) | 0 (0.0) | |||
| MA | 63 | 0.594 | 109 (86.5) | 17 (13.5) | 46 (73.0) | 17 (27.0) | 0 (0.0) | |||
| MO | 89 | 1.000 | 164 (92.1) | 14 (7.9) | 75 (84.3) | 14 (15.7) | 0 (0.0) | |||
| males | controls | 64 | 1.000 | 121 (94.5) | 7 (5.5) | 57 (89.1) | 7 (10.9) | 0 (0.0) | ||
| migraine | 64 | 1.000 | 118 (92.2) | 10 (7.8) | 54 (84.4) | 10 (15.6) | 0 (0.0) | |||
| MA | 21 | 1.000 | 40 (95.2) | 2 (4.8) | 19 (90.5) | 2 (9.5) | 0 (0.0) | |||
| MO | 43 | 1.000 | 78 (90.7) | 8 (9.3) | 35 (81.4) | 8 (18.6) | 0 (0.0) | |||
| Yilmaz 2010 (18) | all | controls | 96 | 0.590 | 174 (90.6) | 18 (9.4) | 79 (82.3) | 16 (16.7) | 1 (1.0) | |
| MO | 67 | 0.233 | 97 (72.4) | 37 (27.6) | 37 (55.2) | 23 (34.3) | 7 (10.4) | |||
| females | controls | 83 | 0.455 | 152 (91.6) | 14 (8.4) | 70 (84.3) | 12 (14.5) | 1 (1.2) | ||
| MO | 57 | 0.308 | 83 (72.8) | 31 (27.2) | 32 (56.1) | 19 (33.3) | 6 (10.5) | |||
| males | controls | 13 | 1.000 | 22 (84.6) | 4 (15.4) | 9 (69.2) | 4 (30.8) | 0 (0.0) | ||
| MO | 10 | 1.000 | 14 (70.0) | 6 (30.0) | 5 (50.0) | 4 (40.0) | 1 (10.0) | |||
| Pappa 2010 (22) | all | controls | 178 | 0.680 | 321 (90.2) | 35 (9.8) | 145 (81.5) | 31 (17.4) | 2 (1.1) | |
| MO | 103 | 1.000 | 192 (93.2) | 14 (6.8) | 89 (86.4) | 14 (13.6) | 0 (0) | |||
| females | controls | 60 | 0.516 | 107 (89.2) | 13 (10.8) | 48 (80.0) | 11 (18.3) | 1 (1.7) | ||
| MO | 57 | 1.000 | 105 (92.1) | 9 (7.9) | 48 (84.2) | 9 (15.8) | 0 (0.0) | |||
| males | controls | 118 | 1.000 | 214 (90.7) | 22 (9.3) | 97 (82.2) | 20 (16.9) | 1 (0.8) | ||
| MO | 46 | 1.000 | 87 (94.6) | 5 (5.4) | 41 (89.1) | 5 (10.9) | 0 (0.0) | |||
| TNF-beta 252A>G (rs909253) polymorphism | ||||||||||
| Allele frequencies, n (%) | Genotype frequencies, n (%) | |||||||||
| Author | Participants | Disease status | Study size | HWE | A | G | AA | AG | GG | |
| Trabace 2002 (20) | all | controls | 101 | 0.404 | 124 (61.4) | 78 (38.6) | 40 (39.6) | 44 (43.6) | 17 (16.8) | |
| migraine | 77 | 0.546 | 115 (74.7) | 39 (25.3) | 44 (57.1) | 27 (35.1) | 6 (7.8) | |||
| MA | 30 | 0.106 | 41 (68.3) | 19 (31.7) | 16 (53.3) | 9 (30.0) | 5 (16.7) | |||
| MO | 47 | 0.656 | 74 (78.72) | 20 (21.28) | 28 (59.57) | 18 (38.30) | 1 (2.13) | |||
| females | controls | 43 | 0.391 | 67 (77.9) | 19 (22.1) | 27 (62.8) | 13 (30.2) | 3 (7.0) | ||
| migraine | 60 | 0.345 | 87 (72.5) | 33 (27.5) | 33 (55.0) | 21 (35.0) | 6 (10.0) | |||
| MA | 25 | 0.230 | 31 (62.0) | 19 (38.0) | 11 (44.0) | 9 (36.0) | 5 (20.0) | |||
| MO | 35 | 1.000 | 56 (80.0) | 14 (20.0) | 22 (62.9) | 12 (34.3) | 1 (2.9) | |||
| males | controls | 58 | 0.328 | 84 (72.4) | 32 (27.6) | 32 (55.2) | 20 (34.5) | 6 (10.3) | ||
| migraine | 17 | 1.000 | 28 (82.4) | 6 (17.6) | 11 (64.7) | 6 (35.3) | 0 (0.0) | |||
| MA | 5 | --- | 10 (100.0) | 0 (0.0) | 5 (100.0) | 0 (0.0) | 0 (0.0) | |||
| MO | 12 | 0.536 | 18 (75.0) | 6 (25.0) | 6 (50.0) | 6 (50.0) | 0 (0.0) | |||
| Lee 2007 (21) | all/females | controls | 382 | 0.915 | 439 (57.5) | 325 (42.5) | 125 (32.7) | 189 (49.5) | 68 (17.8) | |
| migraine | 439 | 0.070 | 467 (53.2) | 411 (46.8) | 134 (30.5) | 199 (45.3) | 106 (24.1) | |||
| MA | 65 | 0.803 | 69 (53.1) | 61 (46.9) | 19 (29.2) | 31 (47.7) | 15 (23.1) | |||
| MO | 327 | 0.118 | 347 (53.1) | 307 (46.9) | 99 (30.3) | 149 (45.6) | 79 (24.2) | |||
| Asuni 2009 (19) | all | controls | 278 | 0.597 | 482 (86.7) | 74 (13.3) | 210 (75.5) | 62 (22.3) | 6 (2.2) | |
| MO | 299 | 1.000 | 488 (81.6) | 110 (18.4) | 199 (66.6) | 90 (30.1) | 10 (3.3) | |||
| females | controls | 144 | 1.000 | 244 (84.7) | 44 (15.3) | 103 (71.5) | 38 (26.4) | 3 (2.1) | ||
| MO | 261 | 1.000 | 429 (82.2) | 93 (17.8) | 176 (67.4) | 77 (29.5) | 8 (3.1) | |||
| males | controls | 134 | 0.207 | 238 (88.8) | 30 (11.2) | 107 (79.9) | 24 (17.9) | 3 (2.2) | ||
| MO | 38 | 1.000 | 59 (77.6) | 17 (22.4) | 23 (60.5) | 13 (34.2) | 2 (5.3) | |||
| Schürks 2009 (17) | all/females | controls | 19,269 | 0.557 | 25,570 (66.4) | 12,968 (33.6) | 8501 (44.1) | 8568 (44.5) | 2200 (11.4) | |
| migraine | 4332 | 0.564 | 5738 (66.2) | 2926 (33.8) | 1891 (43.7) | 1956 (45.2) | 485 (11.2) | |||
| MA | 1213 | 0.315 | 1597 (65.8) | 829 (34.2) | 517 (42.6) | 563 (46.4) | 133 (11.0) | |||
| MO | 1824 | 0.528 | 2420 (66.3) | 1228 (33.7) | 809 (44.4) | 802 (44.0) | 213 (11.7) | |||
| Ghosh 2010 (14) | all | controls | 216 | 0.858 | 328 (75.9) | 104 (24.1) | 125 (57.9) | 78 (36.1) | 13 (6.0) | |
| migraine | 216 | 0.354 | 328 (75.9) | 104 (24.1) | 127 (58.8) | 74 (34.3) | 15 (6.9) | |||
| MA | 84 | 0.162 | 125 (74.4) | 43 (25.6) | 49 (58.3) | 27 (32.1) | 8 (9.5) | |||
| MO | 132 | 1.000 | 203 (76.9) | 61 (23.1) | 78 (59.1) | 47 (35.6) | 7 (5.3) | |||
| females | controls | 152 | 0.467 | 241 (79.3) | 63 (20.7) | 97 (63.8) | 47 (30.9) | 8 (5.3) | ||
| migraine | 152 | 0.359 | 234 (77.0) | 70 (23.0) | 92 (60.5) | 50 (32.9) | 10 (6.6) | |||
| MA | 63 | 0.092 | 96 (76.2) | 30 (23.8) | 39 (61.9) | 18 (28.6) | 6 (9.5) | |||
| MO | 89 | 1.000 | 138 (77.5) | 40 (22.5) | 53 (59.6) | 32 (36.0) | 4 (4.5) | |||
| males | controls | 64 | 0.563 | 87 (68.0) | 41 (32.0) | 28 (43.8) | 31 (48.4) | 5 (7.8) | ||
| migraine | 64 | 0.753 | 94 (73.4) | 34 (26.6) | 35 (54.7) | 24 (37.5) | 5 (7.8) | |||
| MA | 21 | 1.000 | 29 (69.0) | 13 (31.0) | 10 (47.6) | 9 (42.9) | 2 (9.5) | |||
| MO | 43 | 0.681 | 65 (75.6) | 21 (24.4) | 25 (58.1) | 15 (34.9) | 3 (7.0) | |||
| Pappa 2010 (22) | all | controls | 178 | 0.503 | 279 (78.4) | 77 (21.6) | 111 (62.4) | 57 (32.0) | 10 (5.6) | |
| MO | 103 | 0.747 | 167 (81.1) | 39 (18.9) | 68 (66.0) | 31 (30.1) | 4 (3.9) | |||
| females | controls | 60 | 0.709 | 95 (79.2) | 25 (20.8) | 38 (63.3) | 19 (31.7) | 3 (5.0) | ||
| MO | 57 | 1.000 | 94 (82.5) | 20 (17.5) | 38 (66.6) | 18 (31.6) | 1 (1.8) | |||
| males | controls | 118 | 0.590 | 184 (78.0) | 52 (22.0) | 73 (61.9) | 38 (32.2) | 7 (5.9) | ||
| MO | 46 | 0.366 | 73 (79.3) | 19 (20.7) | 30 (65.2) | 13 (28.3) | 3 (6.5) | |||
| TNF-alpha -238G>A (rs361525) polymorphism | ||||||||||
| - | Allele frequencies, n (%) | Genotype frequencies, n (%) | ||||||||
| Author | Participants | Disease status | Study size | HWE | G | A | GG | GA | AA | |
| Schürks 2009 (17) | all/females | controls | 20,425 | 0.006 | 38,780 (94.9) | 2070 (5.1) | 18,427 (90.2) | 1926 (9.4) | 72 (0.4) | |
| migraine | 4577 | 0.431 | 8705 (95.1) | 449 (4.9) | 4136 (90.4) | 433 (9.5) | 8 (0.2) | |||
| MA | 1275 | 0.763 | 2422 (95.0) | 128 (5.0) | 1149 (90.1) | 124 (9.7) | 2 (0.2) | |||
| MO | 1951 | 0.784 | 3730 (95.6) | 172 (4.4) | 1783 (91.4) | 164 (8.4) | 4 (0.2) | |||
| Pappa 2010 (22) | all | controls | 178 | 1.000 | 348 (97.8) | 8 (2.2) | 170 (95.5) | 8 (4.5) | 0 (0.0) | |
| MO | 103 | 1.000 | 199 (96.6) | 7 (3.4) | 96 (93.2) | 7 (6.8) | 0 (0.0) | |||
| females | controls | 60 | 1.000 | 119 (99.2) | 1 (0.8) | 59 (98.3) | 1 (1.7) | 0 (0.0) | ||
| MO | 57 | 1.000 | 111 (97.4) | 3 (2.6) | 54 (94.7) | 3 (5.3) | 0 (0.0) | |||
| males | controls | 118 | 1.000 | 229 (97.0) | 7 (3.0) | 111 (94.1) | 7 (5.9) | 0 (0.0) | ||
| MO | 46 | 1.000 | 88 (95.7) | 4 (4.3) | 42 (91.3) | 4 (8.7) | 0 (0.0) | |||
| TNF-alpha -376G>A (rs1800750) polymorphism | ||||||||||
| Allele frequencies, n (%) | Genotype frequencies, n (%) | |||||||||
| Author | Gender | Disease status | Study size | HWE | G | A | GG | GA | AA | |
| Schürks 2009 (17) | all/females | controls | 20,425 | 0.002 | 40,283 (98.6) | 567 (1.4) | 19,869 (97.3) | 545 (2.7) | 11 (0.1) | |
| migraine | 4578 | 0.307 | 9012 (98.4) | 144 (1.6) | 4436 (96.9) | 140 (3.1) | 2 (0.04) | |||
| MA | 1276 | 0.374 | 2504 (98.1) | 48 (1.9) | 1229 (96.3) | 46 (3.6) | 1 (0.1) | |||
| MO | 1951 | 1.000 | 3851 (98.7) | 51 (1.3) | 1900 (97.4) | 51 (2.6) | 0 (0.0) | |||
| Pappa 2010 (22) | all | controls | 178 | --- | 356 (100.0) | 0 (0.0) | 178 (100.0) | 0 (0.0) | 0 (0.0) | |
| MO | 103 | 1.000 | 205 (99.5) | 1 (0.5) | 102 (99.0) | 1 (1.0) | 0 (0.0) | |||
| females | controls | 60 | --- | 120 (100) | 0 (0.0) | 60 (100) | 0 (0.0) | 0 (0.0) | ||
| MO | 57 | 1.000 | 113 (99.1) | 1 (0.9) | 56 (98.2) | 1 (1.8) | 0 (0.0) | |||
| males | controls | 118 | --- | 236 (100) | 0 (0.0) | 118 (100) | 0 (0.0) | 0 (0.0) | ||
| MO | 46 | --- | 92 (100) | 0 (0.0) | 46 (100) | 0 (0.0) | 0 (0.0) | |||
TNF: tumor necrosis factor; HWE: p value from exact test for the Hardy-Weinberg Equilibrium; MA: migraine with aura; MO: migraine without aura.