. Author manuscript; available in PMC: 2013 Feb 1.

Published in final edited form as: Circ Cardiovasc Genet. 2011 Dec 23;5(1):100–112. doi: 10.1161/CIRCGENETICS.111.961292

Table 1.

Meta-analysis results: ABI-SNP associations with p<10⁻⁵ in the primary discovery analysis with population isolates excluded.

SNP	Chr	Physical Position	Closest Gene	Risk/Non-risk Allele	Risk Allele frequency	Meta-analysis	N	Beta	SE	P value	P _het
rs10757269	9	22062264	CDKN2B	G/A	0.49	ABI Discovery	35036	−0.0056	0.001	2.46E-08	0.23
						ABI Replication	16672	−0.0035	0.0015	1.76E-02	0.67
						ABI Combined	51708	−0.0049	0.0008	2.65E-09	0.38
						PAD^† Discovery	34555	0.0849	0.0296	4.15E-03	0.32
rs4659996	1	238912747	GREM2	A/G	0.48	ABI Discovery	28087	−0.006	0.0012	4.44E-07	0.34
						ABI Replication	16658	−0.0018	0.0016	2.67E-01	0.65
						ABI Combined	44745	−0.0045	0.001	2.12E-06	0.32
						PAD Discovery	27574	0.0725	0.0319	2.31E-02	0.52
rs7003385	8	41705907	ANK1^‡	T/C	0.67	ABI Discovery	35375	−0.0053	0.0011	5.24E-07	0.49
						ABI Replication	16690	−0.002	0.0016	2.20E-01	0.52
						ABI Combined	52065	−0.0043	0.0009	1.11E-06	0.43
						PAD Discovery	34903	0.0838	0.0314	7.57E-03	0.24
rs819750	1	99469651	LPPR4^‡	G/T	0.12	ABI Discovery	35278	−0.007	0.0015	3.64E-06	0.51
						ABI Replication	16660	0.0022	0.0023	3.22E-01	0.99
						ABI Combined	51938	−0.0041	0.0013	1.01E-03	0.31
						PAD Discovery	34780	0.1068	0.0437	1.45E-02	0.06
rs9485528	6	102221473	GRIK2^‡	A/G	0.17	ABI Discovery	35339	−0.0061	0.0013	4.63E-06	0.78
						ABI Replication	16679	0.0002	0.002	9.24E-01	0.63
						ABI Combined	52018	−0.0041	0.0011	1.77E-04	0.48
						PAD Discovery	34850	0.1172	0.0380	2.02E-03	0.80
rs722453	7	84037497	SEMA3A	G/A	0.42	ABI Discovery	26200	−0.0054	0.0012	6.43E-06	0.69
						ABI Replication	6300	−0.0046	0.0025	5.74E-02	0.08
						ABI Combined	32500	−0.0052	0.0011	1.02E-06	0.59
						PAD Discovery	25706	0.0575	0.0318	7.05E-02	0.63
rs16824978	2	211380306	CPS1	T/C	0.25	ABI Discovery	34950	−0.0054	0.0012	7.77E-06	0.37
						ABI Replication	14340	0.0000	0.0019	9.94E-01	0.22
						ABI Combined	49290	−0.0039	0.001	1.48E-04	0.11
						PAD Discovery	34518	0.0760	0.0343	2.65E-02	0.39

P_het= p value for heterogeneity

^‡

SNP is located within the gene; rs819750 is within 60kb of the gene

^†

PAD discovery: ABI≤0.9 vs. ABI>0.9