Table 2.
Meta-analysis results: SNP associations for PAD (ABI ≤0.9 vs ABI >0.9) with p<10−5 with population isolates excluded.
| SNP | Chr | Physical Position | Closest Gene | Risk/Non- risk Allele | Risk Allele frequency | N | OR | 95% Confidence Interval | P value | P het |
|---|---|---|---|---|---|---|---|---|---|---|
| rs6584389 | 10 | 102459392 | PAX2 | C/A | 0.50 | 24474 | 1.17 | (1.10, 1.25) | 2.34E-06 | 0.37 |
|
|
||||||||||
| rs9998941 | 4 | 162544312 | FSTL5* | A/G | 0.23 | 34670 | 1.18 | (1.10, 1.27) | 2.34E-06 | 0.61 |
|
|
||||||||||
| rs11751656 | 6 | 42751046 | UBR2* | G/A | 0.07 | 27470 | 1.61 | (1.32, 1.96) | 2.46E-06 | 0.75 |
|
|
||||||||||
| rs4535726 | 8 | 68938371 | DEPDC2 | T/C | 0.20 | 34915 | 1.18 | (1.10, 1.26) | 3.79E-06 | 0.01 |
|
|
||||||||||
| rs2090205 | 17 | 73897869 | PGS1* | A/C | 0.24 | 34912 | 1.16 | (1.09, 1.24) | 5.01E-06 | 0.17 |
|
|
||||||||||
| rs11933540 | 4 | 25729099 | RBPJ | C/T | 0.30 | 34830 | 1.15 | (1.08, 1.23) | 9.86E-06 | 0.08 |
Phet= p value for heterogeneity
*
SNP is located within the gene