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. 2011 Dec 5;3(1):9. doi: 10.1186/1868-7083-3-9

Figure 1.

Figure 1

Overview of the hypoxia inducible factor (HIF) pathway. In normoxic conditions, HIF-1α binds to VHL at specific proline residues leading to ubiquitination and proteosomal degradation. During hypoxia, HIF-1α no longer binds to VHL and accumulates. This leads to formation of the hypoxia response element and subsequent transcription (HIF-1β also known as ARNT (aryl hydrocarbon receptor nuclear translocator), cJUN - jun proto-oncogene, CREB - cAMP responsive element binding protein 1, EP300 - E1A binding protein p300).