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Roles Prx1 and Prx6 in tumor progression and metastasis through TLR4-MyD88 signaling. Cancer cells secrete Prx1 and activate TLR4-MyD88 signaling in cancer and normal cells to help progression in host.(138) Prx6 also helps growth and metastasis of cancer cells through its GSH peroxidase and phospholidase A2 activities.(145,152) We suggest a cooperation of extracellular Prx1 and cytoplasmic Prx6 in tumor progression through TLR4-MyD88 signaling (see text).
