Table 4.

Augmentation index.

Population	N	Therapy	Study period	mean ± SD	min–max
Renal patients	6	N/A	N/A#	26.1 ± 13.9*	13.3–52.0
Diabetic patients	8	Metformin	cont	5.9 ± 9.4**	−8.0–22.0
Diabetic patients	8	Metformin	discont	14.3 ± 18.9**	1.0–55.0
Diabetic patients	8	Metformin + SA	cont	9.0 ± 13.0∗∗, ∗∗∗	−15.0–24.0
Diabetic patients	8	Metformin + SA	discont	16.3 ± 16.0∗∗, ∗∗∗	−6.0–32.0
Healthy volunteers	12	N/A	N/A	−6.0 ± 14.2	−25.7–31.7

SA: sulfonylurea; SD: standard deviation.

Cont: continuation of therapy; discount: 2 weeks of therapy discontinuation.

^#visit 1, 2, and 3 and averaged (see materials and methods).

*P = 0.001 versus healthy volunteers.

**P < 0.05 versus healthy volunteers.

***P < 0.05 versus diabetic patients on metformin only.