Table 1.
Age-associated changes in PGs and TxA2 and their synthases and receptors.
| Entity | Tissue | Age | Change | References |
|---|---|---|---|---|
| COX1/2 (hum, r, m) | Mesenteric microvessels | Adult, aged | Increase | [21, 29, 33, 34, 42, 63, 84–86] |
| PGI2 (hum) | Blood | Adolescent, aged | Decrease | [112, 116] |
| PGIS (r) | Aorta, coronary artery in heart | Adults, aged | Increase | [85, 86, 110, 120] |
| IP (r) | Aorta | Adults, aged | Decrease | [84, 85, 121] |
| PGE2 (r) | Coronary artery in heart | Aged | Increase | [120] |
| cPGES (r), | Aorta | Old adult | N/S | [84] |
| mPGES-1 (r) | Aorta | Old adult | N/S | [84] |
| mPGES-2 (r) | Aorta | Old adult | Increase | [84] |
| EP1–3 (r) | Aorta | Old adult | N/S | [84] |
| EP4 (r) | Aorta | Old adult | Increase | [84] |
| PGF2α (ham, r) | Aorta | Aged | Increase | [110, 148] |
| PGFS (r) | Aorta | Old adult | Increase | [84] |
| FP (r) | Aorta | Old adult | N/S | [84] |
| PGDS (r) | Aorta | Old adult | Increase | [84] |
| DP (r) | Aorta | Old adult | N/S | [84] |
| TxA2 (r) | Aorta or mesenteric artery | Increase | [42, 86, 172] | |
| TXS (r) | Aorta | Old adult | Increase | [84] |
| TP (r) | Aorta | Old adult | N/S | [84] |
hum: human; ham: hamster; r: rat; m: mouse; N/S: not significant.
Definition of age groups: human, adolescent, 13–19 years; adult, 20–60 years; aged, >60 years. Hamster, aged, >18 months. Rat, young adult, 3–6 months; old adult, 6–18 months; aged >24 months.