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. Author manuscript; available in PMC: 2013 Mar 7.
Published in final edited form as: J Med Chem. 2012 Feb 16;55(5):2406–2415. doi: 10.1021/jm201690h

Table 2.

Estimation of VT from 2TC model in two monkeys injected with [18F]9 at baseline, after treatment with ciproxifan and after treatment with 9.

Region Monkey# 1 Vt
 Monkey# 2 Vt
 Mean Vt decrease (%)
Baseline Ciproxifan pretreatment 9 pretreatment Baseline Ciproxifan pretreatment 9 pretreatment Ciproxifan 9 pretreatment
Frontal cortex 64.1 43.5 29.5 42.1 26.7 16.4 -34 -58
Striatum 54.7 42.7 29.1 45.3 31.6 19.7 -26 -52
Hippocampus 60.4 45.3 31.2 50.8 30.4 20.8 -33 -54
Thalamus 53.7 40.8 29.9 49.9 29.4 19.4 -33 -53
Cerebellum 42.0 33.5 24.8 28.5 19.6 12.0 -26 -49