Table 1.
Effects of single and repeated EEM administration on serum insulin level and ISI in normal and diabetic mice.
| Group | Single administration | Repeated administration | ||
|---|---|---|---|---|
| Serum insulin (mU/L) | ISI | Serum insulin (mU/L) | ISI | |
| Normal control | 11.80 ± 0.83 | −1.88 ± 0.06 | 11.49 ± 1.17 | −1.85 ± 0.04 |
| Normal + 2 g/kg EEM | 11.65 ± 0.44 | −1.88 ± 0.04 | 11.68 ± 0.60 | −1.87 ± 0.04 |
| Normal + 4 g/kg EEM | 11.60 ± 0.79 | −1.86 ± 0.06 | 11.55 ± 0.63 | −1.86 ± 0.05 |
| Normal + 8 g/kg EEM | 11.06 ± 0.30 | −1.86 ± 0.05 | 11.67 ± 0.64 | −1.86 ± 0.05 |
| Normal + glibenclamide | 11.91 ± 0.36 | −1.89 ± 0.04 | 11.54 ± 0.75 | −1.85 ± 0.06 |
| Diabetic control | 16.74 ± 0.53* | −2.45 ± 0.05* | 14.81 ± 1.04* | −2.48 ± 0.05* |
| Diabetic + 2 g/kg EEM | 16.43 ± 0.43 | −2.44 ± 0.05 | 14.65 ± 1.88 | −2.48 ± 0.08 |
| Diabetic + 4 g/kg EEM | 16.01 ± 0.53 | −2.43 ± 0.03 | 11.88 ± 0.90 | −2.04 ± 0.08# |
| Diabetic + 8 g/kg EEM | 16.07 ± 0.95 | −2.42 ± 0.04 | 11.68 ± 0.81 | −2.03 ± 0.05 # |
| Diabetic + glibenclamide | 36.83 ± 4.82# | −2.40 ± 0.09 | 39.15 ± 6.55# | −2.42 ± 0.09 |
Insulin sensitivity index (ISI) = log (1/fasting plasma glucose × serum insulin). Data are expressed as mean ± SD, n = 10 mice per group. *P < 0.01 when compared to normal control. # P < 0.01 when compared to diabetic control.