TABLE 2.

Parameter Estimates^* for 4K Model Applied to 16 Mouse Small-Animal PET Studies

Mouse study	Muscle				Liver				Input Function
	K1 × 10−2	k2 × 10−1	k3 × 10−2	k4× 10−3	K1 × 10−1	k2 × 100	k3 × 10−3	k4 × 10−3	A1 ×10−2	A2 × 10−3	A3 × 10−4	λ1× 100	λ2 × 10−1	λ3× 10−2	λ4 ×100
m09940	1.60	2.35	20.9	2.95	5.70	1.10	7.58	1.67	12.1	2.74	6.69	11.2	1.53	2.43	41.0
m10296	3.36	4.70	16.6	31.2	5.38	1.08	11.1	2.41	2.72	4.99	28.5	1.47	1.08	1.92	41.0
m10610	2.55	3.72	31.7	4.50	5.42	1.25	7.74	1.63	2.60	5.01	2.90	1.60	1.28	1.64	41.0
m10861	3.30	4.75	17.3	1.90	5.59	1.19	12.4	2.63	5.32	8.80	5.92	4.30	0.70	0.10	41.0
m10911	3.12	4.58	37.7	3.32	5.30	1.66	22.2	3.58	3.63	14.3	5.33	3.70	1.40	0.21	41.0
m11043	3.88	5.42	25.8	2.28	5.35	1.58	25.8	4.07	31.0	12.1	4.46	10.5	1.45	0.71	41.0
m11082	3.92	5.37	17.4	2.82	5.34	1.48	17.0	2.83	8.14	8.53	2.62	9.05	1.21	0.54	41.0
m11122	3.91	5.64	41.5	3.23	5.35	1.43	15.9	2.87	8.74	6.37	4.30	8.98	1.14	1.23	41.0
m11467	2.87	4.22	22.1	12.6	5.57	1.27	21.1	3.83	7.19	5.88	6.66	5.28	1.34	0.47	41.0
m17156	1.88	2.39	0.78	0.15	5.31	1.44	2.83	0.60	8.50	3.29	31.5	13.7	3.01	2.50	41.0
m17332	1.58	2.18	2.40	0.48	6.16	1.00	10.9	2.50	2.94	1.44	19.6	7.21	3.67	2.34	41.0
m17385	3.81	5.34	21.7	34.7	5.36	1.37	21.3	4.10	12.0	4.59	38.8	6.56	1.81	2.23	41.0
m17437	2.83	4.29	9.29	36.3	5.45	1.32	11.7	2.54	6.40	2.61	29.4	9.33	3.84	1.39	41.0
m17464	1.28	1.76	2.44	0.51	5.44	1.27	5.67	1.19	7.10	7.22	35.0	8.92	2.41	1.50	41.0
m17540	2.03	2.87	3.92	0.83	5.31	1.22	5.07	1.07	2.98	5.34	45.4	1.92	1.57	1.38	41.0
m17709	2.21	3.07	4.80	1.13	5.23	1.63	14.5	2.77	1.63	8.31	32.6	1.11	1.02	1.54	41.0

^*%CVs for each parameter estimate were calculated based on the covariance matrix for each fitted model (not shown); average %CV for all 240 estimated parameters is 20% ± 22%. Units are the same as shown in Table 1.