Table 1.
Correlations of Dickkopf-1 expression with the clinicopathological features of gastric cancer.
Features | No. of cases | Dickkopf-1 expression | P | |
---|---|---|---|---|
High | Low | |||
Age (years) | 328 | 57.2 ± 9.6 | 61.9 ± 11.8 | NS |
Gender | ||||
Male | 235 | 133 | 102 | NS |
Female | 93 | 62 | 31 | |
Tumor Location | ||||
Proximal | 42 | 27 | 15 | NS |
Middle | 123 | 70 | 53 | |
Distal | 163 | 97 | 66 | |
Tumor size | ||||
<5 cm | 192 | 116 | 76 | NS |
≥5 cm | 136 | 79 | 57 | |
Lauren classification | ||||
Intestinal | 168 | 100 | 68 | NS |
Diffuse | 160 | 95 | 65 | |
Histology | ||||
Papillary adenocarcinoma | 12 | 5 | 7 | NS |
Tubular adenocarcinoma | 245 | 158 | 87 | |
Mucinous adenocarcinoma | 22 | 12 | 10 | |
Signet-ring cell | 49 | 20 | 29 | |
Histologic differentiation | ||||
Well-moderately | 96 | 61 | 35 | NS |
Poorly | 220 | 132 | 88 | |
Other | 3 | 2 | 1 | |
Invasion depth | ||||
T1 | 68 | 14 | 54 | <0.01 |
T2 | 78 | 35 | 43 | |
T3 | 130 | 101 | 29 | |
T4 | 52 | 45 | 7 | |
TNM stages | ||||
I | 68 | 14 | 54 | <0.01 |
II | 78 | 35 | 43 | |
III | 130 | 101 | 29 | |
IV | 52 | 45 | 7 | |
Vessel invasion | ||||
No | 201 | 95 | 106 | <0.01 |
Yes | 127 | 100 | 27 | |
Lymphatic metastasis | ||||
No | 126 | 45 | 81 | <0.01 |
Yes | 202 | 150 | 52 | |
Regional lymph nodes | ||||
PN0 | 125 | 37 | 88 | <0.01 |
PN1 | 102 | 69 | 33 | |
PN2 | 75 | 66 | 9 | |
PN3 | 26 | 23 | 3 | |
Distant metastasis | ||||
No | 282 | 155 | 127 | <0.01 |
Yes | 46 | 40 | 6 |
“NS” refers to no significance.