Table 2.
Number of mutations in each of the groups in which UniProt divides the protein kinase superfamily
| Group | Disease | Neutral | Total |
|---|---|---|---|
| TK † | 496 | 565 | 1061 |
| TKL † | 172 | 151 | 323 |
| Atypical_PI3-PI4 † | 49 | 138 | 187 |
| CAMK † | 40 | 518 | 558 |
| Other | 36 | 411 | 447 |
| RGC † | 23 | 35 | 58 |
| CMGC † | 18 | 178 | 196 |
| AGC † | 16 | 190 | 206 |
| STE | 7 | 222 | 229 |
| Atypical_ADCK | 6 | 14 | 20 |
| Atypical_Alpha-type | 1 | 88 | 89 |
| CK1 | 1 | 52 | 53 |
| NEK | 0 | 45 | 45 |
| Atypical_RIO | 0 | 14 | 14 |
| Atypical_PDK-BCKDK | 0 | 5 | 5 |
| Atypical_FAST | 0 | 1 | 1 |
Number of mutations in each of the groups in which UniProt divides the protein kinase superfamily. The groups enriched in disease-associated mutations are highlighted by †.