Table 2.

Quantitative summary of gross observations in MIA-induced osteoarthritic rats treated with GCSB-5.

		Control	MIA
			Vehicle	GCSB-5 (mg/kg)		Diclofenac
				300	600	5 mg/kg
Swelling
No change	0	10/10	0/10	1/10	1/10	0/10
Mild	1	0/10	3/10	8/10	6/10	8/10
Severe	2	0/10	7/10	1/10	3/10	2/10
Average score		0.0 ± 0.0	1.7 ± 0.2a	1.0 ± 0.2a,b	1.2 ± 0.2a	1.2 ± 0.1a
Limping
No change	0	10/10	0/10	6/10	5/10	5/10
Mild	1	0/10	7/10	4/10	5/10	5/10
Severe	2	0/10	3/10	0/10	0/10	0/10
Average score		0.0 ± 0.0	1.3 ± 0.2a	0.4 ± 0.2c	0.5 ± 0.2c	0.5 ± 0.2c

GCSB-5 or diclofenac was treated daily for 14 days after 2 weeks of OA induction by intra-articular injection of MIA.

^aDenotes significant differences (P < 0.01) versus the control group.

^b,cDenote significant differences (P < 0.05,   P < 0.01) versus the vehicle-treated MIA group.