Figure 1.
Radiotelemetry recordings of (a) MAP and (b) HR of adult SHRs, at baseline and during treatment with vehicle (control, n = 6), candesartan cilexetil (2 mg/kg/day) alone (n = 7) or in combination with PD123319 (10 mg/kg/day, n = 7), or PD123319 alone. Analogous radiotelemetry recordings of (c) MAP and (d) HR of senescent SHRs, at baseline and during treatment with vehicle (control, n = 10), candesartan cilexetil alone (n = 9) or in combination with PD123319 (n = 9), PD123319 alone (n = 4), or hydralazine (30 mg/kg/day, n = 7). **P < 0.01 versus control (2-way ANOVA).