(a) Ventricular weight to body weight (BW) ratio and (b) left ventricular (LV) volume to body weight ratio of adult SHRs, at baseline and during treatment with vehicle (control, n = 4), candesartan cilexetil (2 mg/kg/day) alone (n = 4), or in combination with PD123319 (10 mg/kg/day, n = 4), and PD123319 alone (n = 7). (c) Ventricular weight to BW ratio and (d) LV volume to BW ratio of senescent SHRs, at baseline and during treatment with vehicle (control, n = 10), candesartan cilexetil (2 mg/kg/day) alone (n = 9), or in combination with PD123319 (10 mg/kg/day, n = 9), PD123319 alone (n = 4), or hydralazine (30 mg/kg/day, n = 7). *P < 0.05 versus control (1-way ANOVA).