Table 1.
Control | Candesartan cilexetil | Candesartan cilexetil + PD123319 | PD123319 | Hydralazine | |
---|---|---|---|---|---|
Body weight (g) | |||||
Adult SHRs | 411 ± 11 | 415 ± 5 | 410 ± 5 | 414 ± 3 | — |
Senescent SHRs | 417 ± 9 | 427 ± 7 | 428 ± 10 | 399 ± 9 | 419 ± 11 |
Ventricular weight (mg) | |||||
Adult SHRs | 1423 ± 23 | 1229 ± 39* | 1207 ± 30* | 1474 ± 48 | — |
Senescent SHRs | 2114 ± 74 | 1796 ± 85* | 1962 ± 86 | 2136 ± 163 | 1952 ± 49 |
Plasma Ang II (pg/mL) | |||||
Adult SHRs | 220 ± 100 | 1597 ± 234* | 2785 ± 817* | 68 ± 18 | — |
Senescent SHRs | 80 ± 10 | 383 ± 89* | 271 ± 51* | 64 ± 23 | 91 ± 16 |
Values are mean ± SEM. *P < 0.05 versus age-matched control (1-way ANOVA).