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. 2012 Mar 4;2012:543062. doi: 10.1155/2012/543062

Table 1.

Effect of drug treatments on body weight, ventricular weight, and plasma Ang II of adult and senescent SHRs.

Control Candesartan cilexetil Candesartan cilexetil + PD123319 PD123319 Hydralazine
Body weight (g)
 Adult SHRs 411 ± 11 415 ± 5 410 ± 5 414 ± 3
 Senescent SHRs 417 ± 9 427 ± 7 428 ± 10 399 ± 9 419 ± 11
Ventricular weight (mg)
 Adult SHRs 1423 ± 23 1229 ± 39* 1207 ± 30* 1474 ± 48
 Senescent SHRs 2114 ± 74 1796 ± 85* 1962 ± 86 2136 ± 163 1952 ± 49
Plasma Ang II (pg/mL)
 Adult SHRs 220 ± 100 1597 ± 234* 2785 ± 817* 68 ± 18
 Senescent SHRs 80 ± 10 383 ± 89* 271 ± 51* 64 ± 23 91 ± 16

Values are mean ± SEM. *P < 0.05 versus age-matched control (1-way ANOVA).