Table 1. Body weight, survival, renal function and morphology in SCID mice injected with cisplatin and different regimens of MVs.
| DAY 4 | DAY 14 | DAY 21 | |||||||||||
| Control | CIS | CIS+siMV | CIS+RNase-MV | CIS+miMV | CIS | CIS+siMV | CIS+RNase-MV | CIS+miMV | CIS | CIS+siMV | CIS+RNase-MV | CIS+miMV | |
| Body weght (g) | 24.3±1.6 | 16.8±1.4 | 19±1.8 | 17.6±1.4 | 18.9±1.3 | - | 15.5±2.1 | - | 20.8±0.17† | - | 14,7±1,9 | - | 23,1±3,3† |
| BUN (mg/dl) | 24±4 | 123±12.6 | 75±10.9* | 109±9.7 | 38±2.15*,† | - | 71±9.4 | - | 26±6† | - | 69±23 | - | 23.3 ±1.2† |
| Crea (mg/dl) | 0.2±0.01 | 0.8±0.2 | 0.56±0.15* | 0.8±0.35 | 0.4±0.05*,† | - | 0.42±0.15 | - | 0.36±0.07† | - | 0.40±0.16 | - | 0.28±0.03† |
| % of survival | 100 | 100 | 100 | 100 | 100 | 0 | 60 | 0 | 80 | 0 | 40 | 0 | 80 |
| Casts (n/HPF) | 0 | 3.7±1.56 | 0.26±0.13* | 2.9±1.65 | 0.1±0.04*,† | - | 0.3±0.3 | - | 0† | - | 0.55±0.23 | - | 0† |
| Tubular Necrosis (n/HPF) | 0 | 3.7±1.03 | 1.8±0.32* | 3.4±0.9 | 0*, † | - | 0.75±0.25 | - | 0† | - | 2.25±0.25 | - | 0† |
Results are expressed as mean±SD; ANOVA with Dunnet’s multicomparison test:
* p<0.05 siMV and miMV treatments vs cisplatin (CIS);
† p<0.05 miMV vs siMV.
CIS = cisplatin injection; CIS+siMV = cisplatin treated with single injection of MVs; CIS+RNase-MV = cisplatin treated with injection of MV pre-treated with RNase; CIS+miMV = cisplatin treated with multiple injection of MVs.