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. 2012 Mar 14;7(3):e33160. doi: 10.1371/journal.pone.0033160

Figure 3. Strategy of identifying hetero-regulatory (HeR) modules.

Figure 3

(A) Calculation of hetero-regulatory similarity (HeRS) score, which is the Pearson correlation coefficient of the functional profile of a kinase and the physical binding profile of a transcription factor. (B) Hierarchical clustering of hetero-regulatory similarity (HeRS) matrix. (C) A toy example of hetero-regulatory module, which is composed of a group of kinases/phosphatases, a group of transcription factors, and their target genes.