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. 2012 Mar 14;7(3):e33160. doi: 10.1371/journal.pone.0033160

Figure 5. Fus3 inhibits filamentous pathway mainly through inactivating Tec1.

Figure 5

Target genes with known function in the two mating pathway kinase related HeR modules, (KP: Ste7, Ste11, Ste20; TF: Ste12, Tec1) and (KP: Fus3;TF: Ste12, Tec1) are shown. The targets of STEs (Ste7, Ste11, Ste20) are enriched with mating pathway genes (green), while the targets of Fus3 are enriched with filamentous pathway genes (red). Deletion of STEs will lead to down-regulation of mating pathway genes, and most of them could be bound by Ste12 and Mcm1 as expected. Deletion of Fus3 mainly up-regulates filamentous pathway genes, which are binding targets of Ste12 and Tec1. Other two filamentous pathway related genes, Dse2 and Dse4, are down-regulated upon Fus3 deletion, and they are inhibitors of filamentous pathway [[32]].