Figure 3. Comparison of Ets1 dimers with and without DNA.

(A) Superimposition of DNA-free Ets1 dimer (blue) (PDB access code 1gvj) with DNA-bound Ets1 dimer (orange). (B) The molecules are superimposed and colored as in A. The charged surface is drawn for one of the Ets1 subunits in (Ets1)₂•2DNA complex and the DNA residues docked to the surface of Ets1 are shown as sticks. The positively and negatively charged surface areas of Ets1 are in blue and red, respectively. In panels A and B the magenta balls highlight the atoms of the N-terminal residues of DNA-free Ets1 that are extended toward the DNA-binding surface of Ets1.