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. 2012 Mar 14;7(3):e33698. doi: 10.1371/journal.pone.0033698

Figure 5. Models of Ets1 binding to widely separated EBS.

Figure 5

(A) Docking of Ets1 homodimer to nucleosomal DNA based on the superimposition of DNA in the (Ets1)2•2DNA structure and the high-resolution structure of a nucleosome core particle (PDB access code 1kx5) [49]. Ets1 molecules are displayed as blue and green cartoons and DNA is displayed as a surface with the strands highlighted in yellow and magenta colors. (B) and (C) Schematic representation of two models of Ets1 cooperative binding to widely separated EBS on promoter DNA: (B) binding via looping of promoter DNA and (C) binding to a nucleosome core particle.