Table 1. SNP associations with preeclampsia (p≤10−6).
Chr | SNP | bp1 | Function | Gene | Alleles2 | MAF(cases) | MAF(controls) | P-value | OR3 (95% CI) |
2 | rs7579169 | 121118124 | intergenic | C/T | 0.4471 | 0.3401 | 3.58×10−7 | 1.57 (1.32–1.87) | |
2 | rs12711941 | 121123383 | intergenic | G/T | 0.4482 | 0.3420 | 4.26×10−7 | 1.56 (1.31–1.86) | |
15 | rs2453274 | 44774202 | intronic | CTDSPL2 | C/T | 0.0462 | 0.0989 | 2.32×10−6 | 0.44 (0.31–0.62) |
13 | rs12431203 | 77488736 | intergenic | G/A | 0.2061 | 0.1303 | 2.45×10−6 | 1.73 (1.38–2.18) | |
21 | rs2826538 | 22188735 | intergenic | T/C | 0.1954 | 0.2782 | 5.93×10−6 | 0.63 (0.52–0.77) | |
2 | rs9332419 | 26322040 | intronic | RAB10 | G/A | 0.3562 | 0.4518 | 6.17×10−6 | 0.67 (0.56–0.80) |
2 | rs4952830 | 46746963 | UTR-5 | ATP6V1E2 | A/G | 0.3343 | 0.4284 | 6.74×10−6 | 0.67 (0.56–0.80) |
2 | rs6542736 | 108415702 | intergenic | G/A | 0.4094 | 0.3167 | 7.31×10−6 | 1.50 (1.25–1.79) | |
1 | rs6660579 | 224916592 | intronic | CNIH3 | C/T | 0.1558 | 0.0924 | 7.80×10−6 | 1.81 (1.39–2.36) |
3 | rs2279720 | 87276699 | synonymous | CHMP2B | G/A | 0.0592 | 0.1128 | 8.66×10−6 | 0.49 (0.36–0.68) |
3 | rs1044499 | 87299075 | synonymous | CHMP2B | A/C | 0.0592 | 0.1128 | 8.66×10−6 | 0.49 (0.36–0.68) |
2 | rs11126375 | 26344787 | intronic | RAB10 | A/G | 0.1645 | 0.2412 | 9.13×10−6 | 0.62 (0.50–0.77) |
4 | rs7677523 | 98965696 | intronic | C4orf37 | T/C | 0.0833 | 0.0379 | 9.51×10−6 | 2.31 (1.58–3.37) |
3 | rs17024019 | 87257423 | intergenic | A/G | 0.0601 | 0.1137 | 9.57×10−6 | 0.50 (0.36–0.68) |
Physical coordinate based on NCBI reference assembly build 37.2.
Major allele/minor allele.
Odds ratio for the minor allele.