Fig. 1.

Experimental concept of intentional marginal ablaion.

A. Radiofrequency electrode (small black dot) was placed at peripheral margin of tumor to simultaneously induce tumor and hepatic parenchymal ablation. B. Overall ablation area. Illustration showing overall ablation area (white circle) includes tumor ablation area and hepatic parenchymal area. C. Selectivity of As₂O₃ effect. Illustration showing coagulated tumor area (A) and coagulated hepatic parenchymal area (B). Each area was measured to verify whether selective antivascular property of As₂O₃ on liver tumor has influence on radiofrequency ablation. Radios of coagulated tumor area versus coagulated hepatic parenchymal area were calculated.