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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Bioorg Med Chem. 2012 Feb 16;20(7):2227–2234. doi: 10.1016/j.bmc.2012.02.022

Scheme 1.

Scheme 1

Synthesis of 1h analogs

Reagents and conditions: (i) ethanol, reflux (85 – 99 %); (ii) H2/Pd-C, ethanol, 25 – 28°C (85 – 96 %); (iii) CH2Cl2, 25 – 28°C (62 – 83 %)