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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Steroids. 2012 Jan 20;77(5):477–483. doi: 10.1016/j.steroids.2012.01.007

Table 2.

Results of the non-compartmental analysis of plasma and tumor 1,25(OH)2D3 concentration versus time data.

Parameter Unit 1,25(OH)2D3 1,25(OH)2D3 + CTA091 +/− CTA091 Ratio
Plasma
   AUC0–8h ng/mL•h 67.4 97.3 1.4
   AUC0-inf ng/mL•h 69.1 102 1.5
   Cmax ng/mL 21.6 33.7 1.6
   Tmax h 0.25 0.5 2
   Vd/F L/kg 0.592 0.469 0.79
   Kel h−1 0.489 0.419 0.86
   t1/2 h 1.42 1.66 1.2
   Cl/F L/h/kg 0.289 0.196 0.68
Tumor
   AUC0–8h ng/g•h 8.39 21.7 2.6
   AUC0-inf ng/g•h 9.18 22.9 2.5
   Cmax ng/g 1.70 4.43 2.6
   Tmax h 2 2 1
   kel h−1 0.355 0.460 1.3
   t1/2 h 1.95 1.51 0.77
Tumor/plasma
   AUC0–h - 0.125 0.22 1.8
   Cmax - 0.079 0.13 1.7

Concentration versus time data were obtained after i.p. administration of 20 µg/kg 1,25(OH)2D3 either alone or in combination with 250 µg/kg of CTA091 to mice bearing subcutaneous H292 lung tumors. AUC0–8h, area under the concentration versus time curve from 0 to 8 h; AUC0-inf, area under the concentration versus time curve from 0 to infinity; Cmax, maximum concentration; Tmax, time of Cmax; Vd/F, apparent volume of distribution; kel, elimination rate constant; t½, half-life; Cl/F, apparent clearance.