Table 1.
Characteristics of the study cohorts investigated for the 2 TERC and 4 TERT candidate SNPs
The Cohorts
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UT | LSADT | 1905 | DLCS | |
Mean age at intake (years (range)) | 68.2 (58.8–80.9) | 78.8 (73.3–94.2) | 93.2 (92.4–93.7) | 100 (99.1–100.3) |
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Females (%) | 100 | 66.1 | 82.3 | 77.1 |
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N (2 TERC candidate SNPs): | 213 | 547 | 125 | 128 |
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MAF of rs12696304 | 0.28 | 0.28 | 0.28 | 0.33 |
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MAF of rs3772190 | 0.26 | 0.26 | 0.25 | 0.33 |
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N (4 TERT candidate SNPs) | 213 | 549 | 175 | 132 |
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MAF of rs2853691 | 0.32 | 0.37 | 0.39 | 0.35 |
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MAF of rs33954691 | 0.11 | 0.11 | 0.12 | 0.11 |
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MAF of rs2736098 | 0.32 | 0.24 | 0.25 | 0.25 |
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MAF of rs2853669 | 0.36 | 0.28 | 0.29 | 0.29 |
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N (mTRFL) | 214 | 468 | 119 | 63 |
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Mean age at mTRFL assessment (years) | 68.2 | 79.3 | 99.7 | 102.2 |
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mTRFL ± SD | 6.25±0.042 | 5.71 ±0.023 | 5.20±0.043 | 5.18±0.06 |
Notes: UT: Unilever Twin Cohort Study, LSADT: the Longitudinal Study of Aging Danish Twins, 1905: the Danish 1905 Birth Cohort Study, DLCS: the Danish Longitudinal Centenarian Study, MAF: minor alleleb frequency, mTRFL: mean terminal restriction fragment length (LTL), SD: standard deviation.