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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Exp Neurol. 2012 Jan 16;234(2):398–404. doi: 10.1016/j.expneurol.2012.01.005

Figure 1. Effect of pregnant serum and TNFα on hippocampal slice excitability.

Figure 1

(A) Representative evoked potentials measured after replacement of control horse serum with serum from nonpregnant or late-pregnant rats using a graded scale (1–5) to compare excitability between groups. (B) Late-pregnant serum caused significant neuronal hyperexcitability that was not seen with nonpregnant or control serum. Addition of soluble tumor necrosis factor receptor 1 (sTNFR1) to late-pregnant serum prevented the increase in neuronal excitability without affecting the responses to control or nonpregnant serum. **p<0.01 vs. control and nonpregnant serum; ## p<0.01 vs. late-pregnant serum –sTNFR1. (C) Addition of 200 ng/ml TNFα to slices caused significantly (p=0.002) increased neuronal excitability. **p<0.01 vs. control.