Skip to main content
. Author manuscript; available in PMC: 2013 Apr 13.
Published in final edited form as: J Mol Biol. 2012 Feb 8;417(5):440–453. doi: 10.1016/j.jmb.2012.01.058

Figure 1.

Figure 1

(A) Overlay of fourteen lowest energy structures of the NOXO1β PX domain. Enhanced τe values for the α1/α2 loop identify conformational diversity at the PtdInsP-binding pocket (arrow). Helices are colored light green, strands dark green, and extended/coil gray. (B) Low-energy structure, rotated 90° on the horizontal axis from A, with conserved secondary structural elements labeled. The fourth β-strand is common to NOXO1β and p47phox. (C) The R40 guanidino group interacts with the C-terminus of α3 and the D125 carboxylate. Interaction of the D43 carboxylate with R46 may mitigate electrostatic repulsion at the D3 position of the inositol ring, allowing binding to PtdIns(3,4,5)P2. Orientation of C matches that of A. Strands are colored dark green, helices light green, and coil gray.