Table 1.

Available Therapeutic Modalities in DN

Current therapy	Emerging therapy
1-Intensive glucose control	1-TZDs/PPAR-gamma agonists
a-Medication	2-ACE-2
b-Pancreatic transplantation	3-Endothelin blockers
2-Blood Pressure Control	4-AGEs inhibitors
a-Affecting RAAS:	5-Vitamin D activation
i. ACEi	6-Inflammation modulation
ii. ARBs
iii. Renin inhibitors
iv. Aldosterone inhibitors
b-Not affecting RAAS:
i. CCB
ii. Beta blockers
iii. Diuretics
3-Dyslipidemia and lipid-lowering drugs
4-Multifactorial intervention