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Stability in apical side during permeability study across Caco-2 monolayers (mean ± SEM; n = 3).
| Stability* (%) | |
|---|---|
| 3-HPG | - |
| Val-3-HPG (5a) | 86.5 ± 0.3 |
| Ile-3-HPG (5b) | 96.6 ± 0.6 |
| Phe-3-HPG (5c) | 3.9 ± 2.0 |
| D-Val-3-HPG (5d) | 98.8 ± 0.1 |
| valacyclovir | 94.7 ± 0.3 |
percentage of ester form in donor solution at 120 min
