Table 2.

Longitudinal Multivariate Association Between Individual Baseline Serum Lipids and Cognition Over 9 Years.

	Cholesterol Coefficient			Cholesterol × Time Examinations 1–3			Cholesterol × Time Examinations 4–6
Blood Cholesterol (mg/dL) per SD Increase	B	p Value	B	p Value	B	p Value
TMT-A
Total cholesterol	−0.009	.678	−0.006	.523	0.003	.528
HDL cholesterol	0.011	.647	0.005	.586	−0.003	.530
Total/HDL cholesterol ratio	−0.013	.569	−0.006	.520	0.003	.509
TMT-B
Total cholesterol	−0.023	.336	0.005	.527	0.001	.846
HDL cholesterol	0.002	.945	−0.001	.979	−0.002	.589
Total/HDL cholesterol ratio	−0.018	.445	0.002	.796	0.004	.427
Pegboard*
Total cholesterol	−0.019	.015	0.001	.683
HDL cholesterol	−0.018	.025	0.003	.161
Total/HDL cholesterol ratio	0.005	.568	−0.002	.526
HVLT-R, Immediate Recall
Total cholesterol	−0.003	.802	0.002	.707	0.001	.619
HDL cholesterol	0.014	.269	−0.003	.543	0.001	.680
Total/HDL cholesterol ratio	−0.013	.317	0.003	.446	−0.001	.850
HVLT-R, Delayed Recall
Total cholesterol	−0.009	.642	−0.002	.719	0.002	.479
HDL cholesterol	0.010	.642	−0.007	.290	0.002	.523
Total/HDL cholesterol ratio	−0.011	.610	0.006	.344	−0.001	.670
MMSE
Total cholesterol	0.024	.613	−0.003	.851	−0.010	.172
HDL cholesterol	−0.045	.333	0.003	.848	0.004	.610
Total/HDL cholesterol ratio	0.025	.584	0.005	.768	−0.009	.259

Notes: Each lipid was analyzed in a separate model controlling for age, race, education, serum creatinine levels, lipid-lowering drug use, depression, and vascular disease. For all cognitive tests, a negative number means better performance.

*The Purdue Pegboard was only available at examinations 1–3.

SD = standard deviation; TMT-A = Trail Making Test, Part A; HDL = high-density lipoprotein; TMT-B = Trail Making Test, Part B; HVLT-R = Hopkins Verbal Learning Test-Revised; MMSE = Mini-Mental State Examination.